Located in the center of the action in downtown Cincinnati - adjacent to the Contemporary Arts Center and across the street from the Aronoff Center for the Arts – 21c Museum Hotel Cincinnati is a 156-room boutique hotel, contemporary art museum and cultural civic center. The museum and hotel is located in the 100-year-old renovated Metropole building which was recently listed on the National Register of Historic Places. The property has 8,000 square feet of exhibition, meeting and event space. Exhibits are open to the public free of charge, 24 hours a day, seven days a week.

The hotel also features a spa offering a range of treatment options such as facials, massages and body wraps; and the Metropole restaurant with a menu that revolves around a custom-built, wood-burning fireplace plus a rooftop bar.

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